Search Results for translational-research-in-breast-cancer

This book describes recent advances in translational research in breast cancer and presents emerging applications of this research that promise to have meaningful impacts on diagnosis and treatment.

Author: Dong-Young Noh

Publisher: Springer Nature

ISBN: 9789813296206

Category: Medical

Page: 630

View: 288

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This book describes recent advances in translational research in breast cancer and presents emerging applications of this research that promise to have meaningful impacts on diagnosis and treatment. It introduces ideas and materials derived from the clinic that have been brought to "the bench" for basic research, as well as findings that have been applied back to "the bedside". Detailed attention is devoted to breast cancer biology and cell signaling pathways and to cancer stem cell and tumor heterogeneity in breast cancer. Various patient-derived research models are discussed, and a further focus is the role of biomarkers in precision medicine for breast cancer patients. Next-generation clinical research receives detailed attention, addressing the increasingly important role of big data in breast cancer research and a wide range of other emerging developments. An entire section is also devoted to the management of women with high-risk breast cancer. Translational Research in Breast Cancer will help clinicians and scientists to optimize their collaboration in order to achieve the common goal of conquering breast cancer.
2021-05-13 By Dong-Young Noh

This book offers a comprehensive introduction to translational efforts in breast cancer, addressing the latest approaches to precision medicine based on the current state of understanding of breast cancer.

Author: Erwei Song

Publisher: Springer

ISBN: 9811060193

Category: Medical

Page: 418

View: 562

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This book offers a comprehensive introduction to translational efforts in breast cancer, addressing the latest approaches to precision medicine based on the current state of understanding of breast cancer. With the latest developments in breast cancer research, our understanding of the genomic changes and the oncogenic signaling cascade of breast cancer has made considerable strides. Further, the immuno-environment has been demonstrated as the barrier to clinical cancer. In addition, major advances in cancer biology, immunology, genomics and metabolism have broken new ground for designing therapeutic approaches and selecting appropriate treatments on the basis of more precise information on the individual patient. As a result of these two trends, a clearer picture of the molecular landscape of breast cancers has facilitated the development of diagnostic, prognostic and predictive biomarkers for clinical oncology. All these aspects are addressed in this volume, which offers a comprehensive resource for researchers, graduate students and oncologists in cancer research.
2018-01-30 By Erwei Song

Medical centers are widely recognized as vital components of the healthcare system.

Author: Ravi Salgia

Publisher: MDPI

ISBN: 9783036503967

Category: Medical

Page: 250

View: 799

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Medical centers are widely recognized as vital components of the healthcare system. However, academic medical centers are differentiated from their community counterparts by their mission, which typically focuses on clinical care, education, and research. Nonetheless, community clinics/hospitals fill a critical need and play a complementary role serving as the primary sites for health care in most communities. Furthermore, it is now increasingly recognized that in addition to physicians, physician-scientists, and other healthcare-related professionals, basic research scientists also contribute significantly to the emerging inter- and cross-disciplinary, team-oriented culture of translational science. Therefore, approaches that combine the knowledge, skills, experience, expertise, and visions of clinicians in academic medical centers and their affiliated community centers and hospitals, together with basic research scientists, are critical in shaping the emerging culture of translational research so that patients from the urban as well as suburban settings can avail the benefits of the latest developments in science and medicine. ‘Integrating Clinical and Translational Research Networks—Building Team Medicine’ is an embodiment of this ethos at the City of Hope National Medical Center in Duarte, California. It includes a series of papers authored by teams of leading clinicians, basic research scientists, and translational researchers. The authors discuss how engaging and collaborating with community-based practices, where the majority of older patients with cancer receive their care, can ensure that these patients receive the highest-quality, evidence-based care. Based on our collective experience at City of Hope, we would like to stress that the success of academic-community collaborative programs not only depends on the goodwill and vision of the participants but also on the medical administration, academic leadership, and policymakers who define the principles and rules by which cooperation within the health care industry occurs. We trust that our experience embodied in this singular compendium will serve as a ‘Rosetta Stone’ for other institutions and practitioners.
2021-01-29 By Ravi Salgia

The key features of the book include: 1) New screening for the development of radioprotectors: radioprotection and anti-cancer effect of β-Glucan (Enterococcus faecalis) 2) Translational perspective on hepatocellular carcinoma 3) ...

Author: Sivapatham Sundaresan

Publisher: BoD – Books on Demand

ISBN: 9781838805340

Category: Medical

Page: 212

View: 354

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Translational research in oncology benefits from an abundance of knowledge resulting from genome-scale studies concerning the molecular pathways involved in tumorigenesis. Translational oncology represents a bridge between basic research and clinical practice in cancer medicine. The vast majority of cancer cases are due to environmental risk factors. Many of these environmental factors are controllable lifestyle choices. Experimental cancer treatments are studied in clinical trials to compare the proposed treatment to the best existing treatment through translational research. The key features of the book include: 1) New screening for the development of radioprotectors: radioprotection and anti-cancer effect of β-Glucan (Enterococcus faecalis) 2) Translational perspective on hepatocellular carcinoma 3) Brachytherapy for endometrial cancer 4) Discovery of small molecule inhibitors for histone methyltransferases in cancer
2021-02-03 By Sivapatham Sundaresan

Author: Daniela Spano

Publisher: Frontiers Media SA

ISBN: 9782889745708

Category: Science

Page: 206

View: 804

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2022-03-03 By Daniela Spano

Exosomes mediate the cross talk between cancer cells and normal or cancer-related stromal cells to regulate tumor ... Sledge G, Visco FM (2007) Shaping the future of biomarker research in breast cancer to ensure clinical relevance.

Author: Erwei Song

Publisher: Springer

ISBN: 9789811060205

Category: Medical

Page: 418

View: 512

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This book offers a comprehensive introduction to translational efforts in breast cancer, addressing the latest approaches to precision medicine based on the current state of understanding of breast cancer. With the latest developments in breast cancer research, our understanding of the genomic changes and the oncogenic signaling cascade of breast cancer has made considerable strides. Further, the immuno-environment has been demonstrated as the barrier to clinical cancer. In addition, major advances in cancer biology, immunology, genomics and metabolism have broken new ground for designing therapeutic approaches and selecting appropriate treatments on the basis of more precise information on the individual patient. As a result of these two trends, a clearer picture of the molecular landscape of breast cancers has facilitated the development of diagnostic, prognostic and predictive biomarkers for clinical oncology. All these aspects are addressed in this volume, which offers a comprehensive resource for researchers, graduate students and oncologists in cancer research.
2017-12-28 By Erwei Song

Breast translational research has markedly evolved over the past few decades and the emerging knowledge has revolutionized our understanding of breast neoplasms. Novel techniques and concepts in studying breast cancer have been developed.

Author: A. M. Shaaban

Publisher:

ISBN: 3318055875

Category:

Page: 74

View: 733

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Breast translational research has markedly evolved over the past few decades and the emerging knowledge has revolutionized our understanding of breast neoplasms. Novel techniques and concepts in studying breast cancer have been developed. These have contributed to the understanding and recognition of this complex disease. This special topic issue on Breast Translational Research provides pertinent and succinct reviews on tumor microenvironment, metabolomics, the role of the calpain family of enzymes, the molecular mechanisms of lymphovascular invasion, and predictors of response to neoadjuvant therapy. It proposes and illustrates a new terminology for the practising pathologist who needs to describe a diagnostically challenging group of breast neoplasms showing dermal analogue differentiation. It also evaluates the role of p40 immunohistochemistry in diagnostic breast pathology. This publication is of special interest to pathologists as well as scientists and members of the breast multidisciplinary team, since it provides a useful overview of pertinent markers and techniques in the field of breast cancer translational research and diagnostic histopathology.
2015-09-03 By A. M. Shaaban

This book presents concise chapters written by internationally respected experts on various important aspects of translational cancer genomics, offering a comprehensive overview of the onco-omics applications in the new era of cancer ...

Author: Erika Ruiz-Garcia

Publisher: Springer Nature

ISBN: 9783030241001

Category: Science

Page: 171

View: 707

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Being a complex disease that affects millions of people world over, cancer research has assumed great significance. Translational cancer research transforms scientific discoveries in the laboratory into clinical application to reduce incidence of cancer, morbidity and mortality. On the other hand, personalized medicine in cancer is the concept that selection of a treatment should be tailored according to the individual patient’s specific genomic characteristics, including mutations, chromosomal aberrations, protein interactions, and SNPs, and even more, taking into account the inmume system, the metabolism and maybe in the next future also the microbiome.
2019-11-11 By Erika Ruiz-Garcia

This issue of the Surgical Oncology Clinics of North America, Guest Edited by Dr. William G. Cance, is devoted to Translational Cancer Research for Surgeons.

Author: William G. Cance

Publisher: Elsevier Health Sciences

ISBN: 9780323227452

Category: Medical

Page: 311

View: 243

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This issue of the Surgical Oncology Clinics of North America, Guest Edited by Dr. William G. Cance, is devoted to Translational Cancer Research for Surgeons. Translational Cancer research aims to move bench research to the bedside by applying basic science toward potential therapies. This issue will present the concepts of translational research and development of targeted therapeutics, and its implications for surgeons. It will show clinical applications for surgeons regarding sarcoma/GIST, melanoma, colorectal cancer, breast cancer, and endocrine cancer.
2013-09-11 By William G. Cance

Despite many years of translational research in breast cancer, very few new biomarkers have been implemented for clinical use beyond estrogen receptor, progesterone receptor, and HER2.

Author: Aleix Prat

Publisher: Frontiers Media SA

ISBN: 9782889637966

Category:

Page: 187

View: 301

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Despite many years of translational research in breast cancer, very few new biomarkers have been implemented for clinical use beyond estrogen receptor, progesterone receptor, and HER2. The main reason is that many promising biomarkers are clinically validated but lack analytical and clinical utility. One explanation is that proper validation of the predictive ability of the biomarker in independent datasets, and with a pre-planned statistical analysis, is not always performed. Thus, there is a need to identify new biomarkers or new ways to subclassify breast cancer patients that are reproducible and easy to implement in the clinical setting but, more importantly, that improve patient’s outcomes.
2020-06-16 By Aleix Prat