Medical

The Genetics of Diabetes Mellitus

Optimistically, the publication of this work on the genetics of diabetes will help to achieve this aim and to establish the concept of genetic heterogeneity of diabetes mellitus.

Author: W. Creutzfeldt

Publisher: Springer Science & Business Media

ISBN: 9783642663321

Category: Medical

Page: 250

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On February 21 and 22, 1975, an International Workshop on the "Genetics of Diabetes Mellitus" was held in Göttingen, West-Germany. This workshop had been organized hy the Department of Medicine, University of Göttingen, and was generously sponsored by the Deutsche Forschungsgemeinschaft. Some forty geneticists and clinicians from Europe and N orth America, working in the field of diabetes both in man and laboratory animals, participated. The 25lectures presented at the workshop are now assembled for publication. Some of the animated discussion which followed the presentations has been included in the final papers by the speakers. Some lectures summarize the recent literature, others present data from recent research. Thus, a comprehensive and modem review of the theoretical and practical problems of diabetes are offered by this volume. related to the genetics The confusion about the mode of inheritance of diabetes mellitus during the last two decades can only be resolved by joint discussions between geneticists interested in diabetes and clinical diabetologists interested in genetics. Knowledge of modem genetics and of the heterogeneity of diabetes mellitus are necessary in order to disentangle the complex scene. Optimistically, the publication of this work on the genetics of diabetes will help to achieve this aim and to establish the concept of genetic heterogeneity of diabetes mellitus. The editors are grateful to Springer-Verlag, Heidelberg, for the prompt publication of these proceedings and to the Farbwerke Hoechst AG, Frankfurt (M), for their contribution to the printing costs.

2012-12-06 By W. Creutzfeldt

Medical

Genetics of Diabetes Mellitus

The text contains chapters from experts in the area who review aspects of the genetics of both type 1 and 2 diabetes mellitus as well as various syndromic forms of diabetes.

Author: William L. Lowe

Publisher: Springer Science & Business Media

ISBN: 0792372522

Category: Medical

Page: 255

View: 552

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Genetics of Diabetes Mellitus is intended to be a resource for both researchers in the field as well as endocrinologists, diabetologists, and geneticists who seek to learn more about this rapidly changing and important field. The text contains chapters from experts in the area who review aspects of the genetics of both type 1 and 2 diabetes mellitus as well as various syndromic forms of diabetes. The chapters are approachable for those who are not experts in the field of genetics but also comprehensive, so as to serve as an important resource for researchers interested in the genetics of diabetes mellitus. A description of basic concepts of the genetics of complex diseases like type 1 and type 2 diabetes is provided as background. Type 1 diabetes is addressed in chapters exploring genetic determinants that affect the autoimmune process characteristic of type 1 diabetes, the role of the insulin gene in the pathogenesis of type 1 diabetes and additional genes that may impact upon the risk of type 1 diabetes. The impact of genetic determinants on the pathophysiology of type 2 diabetes is covered, as are chapters that address specific genes that are important for the development of type 2 diabetes. Finally, syndromic forms of diabetes, including Maturity Onset Diabetes of the Young and mitochondrial diabetes, and the insight that these disorders provide into more common forms of diabetes are reviewed. Thus, this comprehensive and up-to-date text will serve as an important resource for those actively engaged in research in this area and clinicians treating these patients to provide an up-to-date entrée for those seeking to become more knowledgeable in the area.

2001 By William L. Lowe

The Genetics of Diabetes Mellitus

Author: Chrēstos Spyrou Bartsokas

Publisher:

ISBN: OCLC:437126920

Category:

Page: 72

View: 285

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2002 By Chrēstos Spyrou Bartsokas

The genetics of diabetes mellitus

Author:

Publisher:

ISBN: OCLC:441859150

Category:

Page: 40

View: 132

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2001 By

Medical

The Genetics of Type 2 Diabetes and Related Traits

Author: Jose C. Florez

Publisher: Springer

ISBN: 9783319015743

Category: Medical

Page: 576

View: 366

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This book presents the state of the art of type 2 diabetes genetics, from the process of genetic discovery to its interpretation and clinical application, and illustrates a model for other complex human phenotypes.The first section explores genome-wide association studies, the extension of this method to less accessible phenotypes and the arrival of next-generation sequencing. A further section goes beyond genetics to illustrate how other data sources can help interpret genetic data, such as leveraging population diversity, the correlation of genetic associations with physiological measurements, gene expression modulation, environmental factors and our microbial commensals. The third section describes advances in elucidating the complex path from association to function using in-depth sequencing and functional studies of the cellular and molecular effects of genes in the loci identified by genetics. The final section links our current understanding with clinically relevant questions, such as prediction, interactions with drugs or nutrients, and disease prevention, and paints a realistic but hopeful vision of the future.

2016-04-11 By Jose C. Florez

Medical

New Advances in the Genetics and Treatment of Type 1 Diabetes Mellitus and Late Diabetic Complications

T1D is a typical complex and heterogeneous pathology, occurred in genetically predisposing subjects as a result of harmful influence of non-genetic (environmental) factors. This book explores important research in this field.

Author: Dimitry A. Chistiakov

Publisher: Nova Biomedical

ISBN: PSU:000061027886

Category: Medical

Page: 255

View: 337

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Type 1 diabetes (T1D) is caused by the auto-immune destruction of pancreatic cells and is characterised by absolute insulin insufficiency. The disease was thought to be the prevalent type of diabetes in children and adolescents, affecting up to 0.1% of the world population. T1D is a typical complex and heterogeneous pathology, occurred in genetically predisposing subjects as a result of harmful influence of non-genetic (environmental) factors. This book explores important research in this field.

2007 By Dimitry A. Chistiakov

The Genetics of Type 1 Diabetes Family and Population Studies

The family resource is now the largest single collection of it's kind and is used by research groups throughout the world.

Author:

Publisher:

ISBN: OCLC:690664902

Category:

Page:

View: 918

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Type 1 (insulin-dependent) diabetes mellitus is caused by autoimmune destruction of insulin-producing pancreatic ß-cells. Genetic susceptibility is necessary for the development of type 1 diabetes but inheritance does not follow simple Mendelian rules and environmental factors are also involved. Identification of the genes which mediate disease susceptibility should allow recognition of individuals at high risk of disease; this will facilitate the study of environmental factors and possibly the development of strategies for prevention. Further, the characterisation of susceptibility genes will allow a greater understanding of the aetiopathogenesis of type 1 diabetes and may lead to new therapeutic approaches. A major limiting factor, hindering the genetic dissection of type 1 diabetes, has been the lack of a large well-characterised clinical resource for study. This thesis describes how I have established a Repository of immortalised cell lines from large numbers of ethnically matched controls, sporadic type 1 diabetics and type 1 diabetic multiply affected families. The family resource is now the largest single collection of it's kind and is used by research groups throughout the world. Using this resource, I have further characterised HLA-mediated susceptibility to Type 1 diabetes, particularly with regard to age-related heterogeneity and inherited susceptibility. In addition, I have confirmed the existence of linkage of type 1 diabetes to a gene (or genes) within the insulin gene region on chromosome 11p. I have also performed association studies using other candidate genes. These studies have led to a significant advance in the field of the genetics of type 1 diabetes and bequeath a permanent resource for future research.