Search Results for rna-nanotechnology-and-therapeutics

Interest in RNA nanotechnology has increased in recent years as recognition of its potential for applications in nanomedicine has grown.

Author: Peixuan Guo

Publisher: CRC Press

ISBN: 9781466505834

Category: Medical

Page: 611

View: 248

DOWNLOAD & READ
Interest in RNA nanotechnology has increased in recent years as recognition of its potential for applications in nanomedicine has grown. Edited by the world's foremost experts in nanomedicine, this comprehensive, state-of-the-art reference details the latest research developments and challenges in the biophysical and single molecule approaches in R
2013-07-09 By Peixuan Guo

This volume contains a compilation of techniques and laboratory protocols directly related to RNA nanotechnology and its applications in nanobiotechnology and nanomedicine.

Author: Peixuan Guo

Publisher:

ISBN: 1493925628

Category: Biotechnology

Page: 239

View: 275

DOWNLOAD & READ
This volume contains a compilation of techniques and laboratory protocols directly related to RNA nanotechnology and its applications in nanobiotechnology and nanomedicine. The chapters in this book cover a wide range of research methods that can be easily comprehended and carried out in a step-by-step manner by graduate students and postdoctoral fellows from diverse scientific disciplines. Some of the covered topics include various biochemical, biophysical and bioinformatics approaches for analyzing RNA structures and properties; methods to analyze the multi-step assembly process of RNA nanoarchitectures; purification of multifunctional RNA nanoparticles by ultracentrifugation and HPLC; real-time detection of RNA nanoconstructs in vivo; conjugation of imaging, targeting and therapeutic modules to RNA scaffold; and design and characterization of RNA-protein nanostructures. Written in the highly successful Methods of Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and key tips on troubles troubleshooting and avoiding known pitfalls. Cutting-edge and practical, RNA Nanotechnology and Therapeutics: Methods and Protocols propels the field toward new heights by engaging researchers working in the diverse fields of physical, engineering, and life sciences.
2015 By Peixuan Guo

This collection of research articles and reviews covers the latest work in the design, delivery, dynamic abilities, and immune stimulation of RNA nanoparticles which have driven the utilization of their immunomodulatory properties.

Author: Kirill A. Afonin

Publisher: CRC Press

ISBN: 9781000263473

Category: Medical

Page: 1228

View: 587

DOWNLOAD & READ
This collection of research articles and reviews covers the latest work in the design, delivery, dynamic abilities, and immune stimulation of RNA nanoparticles which have driven the utilization of their immunomodulatory properties. The unknown immune properties of nucleic acid nanoparticles have been a major hurdle in their adaptation until the works herein began assessing their structure-activity relationships. This collection chronologically follows the path of investigating the recognition of design components to implementing them into nucleic acid nanostructures. RNA nanotechnology is an emerging platform for therapeutics with increasing clinical relevance as this approach becomes more widely used and approved for the treatment of various diseases. The latest research aims to take advantage of RNA’s modular nature for the design of nanostructures which can interact with their environments to communicate programmed messages with intracellular pathways. In doing so, nanoparticles can be used to elicit or elude responses by the immune system as desired in conjunction with their therapeutic applications. This collection of research articles and reviews covers the latest work in the design, delivery, dynamic abilities, and immune stimulation of RNA nanoparticles which have driven the utilization of their immunomodulatory properties.
2021-07-22 By Kirill A. Afonin

This collection of research articles and reviews covers the latest work in the design, delivery, dynamic abilities, and immune stimulation of RNA nanoparticles which have driven the utilization of their immunomodulatory properties.

Author: Kirill A. Afonin

Publisher: CRC Press

ISBN: 9781000263176

Category: Medical

Page: 1228

View: 166

DOWNLOAD & READ
This collection of research articles and reviews covers the latest work in the design, delivery, dynamic abilities, and immune stimulation of RNA nanoparticles which have driven the utilization of their immunomodulatory properties. The unknown immune properties of nucleic acid nanoparticles have been a major hurdle in their adaptation until the works herein began assessing their structure-activity relationships. This collection chronologically follows the path of investigating the recognition of design components to implementing them into nucleic acid nanostructures. RNA nanotechnology is an emerging platform for therapeutics with increasing clinical relevance as this approach becomes more widely used and approved for the treatment of various diseases. The latest research aims to take advantage of RNA’s modular nature for the design of nanostructures which can interact with their environments to communicate programmed messages with intracellular pathways. In doing so, nanoparticles can be used to elicit or elude responses by the immune system as desired in conjunction with their therapeutic applications.
2021-07-22 By Kirill A. Afonin

This book is a printed edition of the Special Issue Nucleic Acid Architectures for Therapeutics, Diagnostics, Devices and Materials that was published in Nanomaterials

Author: Kirill A. Afonin

Publisher: MDPI

ISBN: 9783039212590

Category: Science

Page: 186

View: 313

DOWNLOAD & READ
This book is a printed edition of the Special Issue Nucleic Acid Architectures for Therapeutics, Diagnostics, Devices and Materials that was published in Nanomaterials
2019-08-06 By Kirill A. Afonin

Nanotechnology for the Delivery of Therapeutic Nucleic Acids, written by world experts in the field of nanotechnology for NA delivery, the contributing authors bring together the state of the art in delivery strategies with strong emphasis ...

Author: Dan Peer

Publisher: CRC Press

ISBN: 9789814411042

Category: Medical

Page: 240

View: 735

DOWNLOAD & READ
Nucleic acid (NA) therapeutics has been extensively studied both in the academia and in the pharmaceutical industry and is still considered the promise for new therapeutic modalities, especially in personalized medicine. The only hurdle that limits the translation of NA therapeutics from an academic idea to the new therapeutic modality is the lack of efficient and safe delivery strategies. Nanotechnology for the Delivery of Therapeutic Nucleic Acids, written by world experts in the field of nanotechnology for NA delivery, the contributing authors bring together the state of the art in delivery strategies with strong emphasis on aspects that are of essence to the pharmaceutical industry, such as stability, general toxicity, immune-toxicity, pharmacokinetics, efficacy, and validation of new drug targets using unique approaches based on exquisite nanotechnology strategies.
2013-03-27 By Dan Peer

Ribonucleic acid (RNA) nanotechnology is a rapidly emerging field that focuses on the nanostructure design, construction, and application in biotechnology and biomedicine.

Author: Sijin Guo

Publisher:

ISBN: OCLC:1180291735

Category: Cancer

Page:

View: 681

DOWNLOAD & READ
Ribonucleic acid (RNA) nanotechnology is a rapidly emerging field that focuses on the nanostructure design, construction, and application in biotechnology and biomedicine. Unlike other biomacromolecules, RNA is more flexible in structure and more versatile in functionality. On the other hand, RNA is a naturally-occurring biopolymer, making them more biocompatible compared to other nanomaterials. Thus, RNA can serve as a building block to construct nanoparticles as drug delivery platform for cancer therapy. This dissertation primarily describes a fundamental study that explores the immune-compatibility of RNA nanoparticles, as well as the use of thermostable RNA nanoparticles to specifically deliver therapeutics for efficient cancer therapy without causing toxicity. Firstly, RNA polygons that have identical size but varying shapes, or same shape but with different sizes were constructed as study model. The RNA nanoparticles were found to be immunologically inert, indicating that RNA nanoparticles are safe drug carriers without triggering immune responses. On the other hand, they can elicit significant immunomodulation by extending the nanoparticles with special sequences. Specifically, this immunomodulation was found to be size, shape, sequence-dependent, demonstrating the potential of using RNA nanoparticles in immunotherapy. Secondly, the use of a thermostable RNA nanoparticle for solubilizing and high-density loading chemotherapeutic drugs for cancer inhibition is reported. Small chemotherapeutic drugs possess significant anti-cancer activity, but their clinical applications were greatly limited by the poor biocompatibility such as water-insolubility. By chemically conjugating water-insoluble drugs to RNA, the RNA nanoparticles dramatically improved drug water-solubility. An ultra-thermostable RNA four-way junction nanoparticle was able to covalently load twenty-four copies of paclitaxel without nanoparticle dissociation or unfolding. After intravenous administration, the resulting RNA-paclitaxel nanoparticles harboring specific cancer targeting ligand significantly inhibited breast cancer tumor in mice. The toxicity in organs and immune responses in mice were almost undetectable. Besides paclitaxel, this RNA-drug conjugation was applied to another anti-cancer drug, camptothecin, and showed significant inhibitory effect on tumor growth. Furthermore, an acid labile linker was developed within RNA-drug conjugates, aiming at controlling pH-responsive drug release in acidic tumor environment to improve drug efficacy. Thirdly, a three-dimensional RNA cube was constructed and explored as a multi-functional drug carrier by incorporation with different therapeutic modules. This multi-functional RNA cube is able to load chemotherapeutic drug, immunostimulatory molecule, or short-interfering RNA for enhanced cellular effects in vitro. What’s more, the RNA cube can be manipulated to become reconfigurable, suggesting the great potential of drug encapsulation and release for in vivo applications. Collectively, these findings demonstrate that RNA nanoparticles can serve as a biocompatible drug delivery platform for effective cancer therapy with favorable safety profile.
2019 By Sijin Guo

ASP All rights reserved Printed in the United States of America Nanoscience and
Nanotechnology Vol . ... FL 33328 , USA RNA interference ( RNAI ) is an
emerging technology in which the introduction of double - stranded RNA ( dsRNA
) into a diverse range ... may also offer improved formulation stability , which is
practically beneficial and may be used in the future clinical studies of siRNA
therapeutics .

Author:

Publisher:

ISBN: UOM:39015039859809

Category: Nanoscience

Page:

View: 731

DOWNLOAD & READ
2006 By

This book targets a wide audience: a broad introduction provides a solid academic background for students, researchers, and scientists who are unfamiliar with the subject, while the in-depth descriptions and discussions are useful for ...

Author: Bin Wang

Publisher: CRC Press

ISBN: 9789814411646

Category: Medical

Page: 466

View: 835

DOWNLOAD & READ
In the past few decades there has been incredible growth in "bionano"-related research, which has been accompanied by numerous publications in this field. Although various compilations address topics related to deoxyribonucleic acid (DNA) and protein, there are few books that focus on determining the structure of ribonucleic acid (RNA) and using RNA as building blocks to construct nanoarchitectures for biomedical and healthcare applications. RNA Nanotechnology is a comprehensive volume that details both the traditional approaches and the latest developments in the field of RNA-related technology. This book targets a wide audience: a broad introduction provides a solid academic background for students, researchers, and scientists who are unfamiliar with the subject, while the in-depth descriptions and discussions are useful for advanced professionals. The book opens with reviews on the basic aspects of RNA biology, computational approaches for predicting RNA structures, and traditional and emerging experimental approaches for probing RNA structures. This section is followed by explorations of the latest research and discoveries in RNA nanotechnology, including the design and construction of RNA-based nanostructures. The final segment of the book includes descriptions and discussions of the potential biological and therapeutic applications of small RNA molecules, such as small/short interfering RNAs (siRNAs), microRNAs (miRNAs), RNA aptamers, and ribozymes.
2014-04-02 By Bin Wang

This book describes a broad area of nanomedicine which involves mainly applications, diseases, and diagnostics.

Author: Ajay Kumar Mishra

Publisher: John Wiley & Sons

ISBN: 9781118635841

Category: Science

Page: 536

View: 363

DOWNLOAD & READ
This book describes a broad area of nanomedicine which involves mainly applications, diseases, and diagnostics. The comprehensive coverage provides researchers, academics, and health specialists with a great tool, that includes techniques applicable to various uses.
2013-02-01 By Ajay Kumar Mishra

Thus we are witnessing the birth of a very exciting time in the development of molecular medicine, which will be based on the methods of RNA technologies. This volume is the first of a series.

Author: Volker A. Erdmann

Publisher: Springer Science & Business Media

ISBN: 3642121683

Category: Medical

Page: 452

View: 650

DOWNLOAD & READ
RNA technologies are the driving forces of modern medicine and biotechnology. They combine the fields of biochemistry, chemistry, molecular biology, cell biology, physics, nanotechnology and bioinformatics. The combination of these topics is set to revolutionize the medicine of tomorrow. After more than 15 years of extensive research in the field of RNA technologies, the first therapeutics are ready to reach the first patients. Thus we are witnessing the birth of a very exciting time in the development of molecular medicine, which will be based on the methods of RNA technologies. This volume is the first of a series. It covers various aspects of RNA interference and microRNAs, although antisense RNA applications, hammerhead ribozyme structure and function as well as non-coding RNAs are also discussed. The authors are internationally highly respected experts in the field of RNA technologies.
2010-09-02 By Volker A. Erdmann

From the nexus of RNA molecular biology and nanoscience has emerged an exciting new field called RNA Nanotechnology.

Author: Ashley Marguerite Schaeffer

Publisher:

ISBN: OCLC:909882062

Category: Cancer

Page: 212

View: 935

DOWNLOAD & READ
From the nexus of RNA molecular biology and nanoscience has emerged an exciting new field called RNA Nanotechnology. For therapeutic application, most studies to date have focused on siRNA, however, an additional advantage of aptamers, splice-site switching oligomers (SSOs), and RNA polymer poly I:C is that they can be designed to inhibit or up-regulate gene expression to promote beneficial anti-cancer response. From a pre-clinical standpoint, there are three very important characteristics that a candidate nanomaterial should possess for RNA delivery. First, it would be a major advantage if the nanomaterial were capable of binding RNA directly. Second, the nanomaterial must be compatible with RNA. Third, the nanomaterial must preserve RNA structure-function. Here we tested a panel of NMs including for their effect on RNA structure-function by various characterization techniques. We found that the surface charge of naked NMs provides a preliminary indication as to their direct interaction with RNA and the cell membrane. Changes in the absorbance spectrum of RNA in the presence of NMs elude to a more specific description of such interactions, such as degradation or binding. Our evidence suggests that MgO is unique in that it directly binds RNA, as well as releases it, in a time-dependent manner. We also show cancer-specific cytotoxicity of a few of the NMs screened under various conditions. The investigations performed within this study elucidate the basic interactions between various NMs and RNA species. Further investigation may proceed based on these data.

RNA interference in vivo : Toward synthetic small inhibitory RNA - based
therapeutics . Meth . ... Controllable self - assembly of nanoparticles for specific
delivery of multiple therapeutic molecules to cancer cells using RNA
nanotechnology .

Author: Shayne C. Gad

Publisher: Wiley-Interscience

ISBN: UOM:39015064951935

Category: Medical

Page: 1659

View: 457

DOWNLOAD & READ
Describes the use of biotechnology to develop pharmaceuticals. This book gives the professional a basic tool to facilitate the development of biotech medicines by bringing together a general overview of biotechnology used in the drug development process, along with a compendium of regulations and validation methods.
2007-06-11 By Shayne C. Gad

Several books have discussed molecular biology and mechanisms involved in cancer, but this text gives an account of molecular therapeutics in cancer relating to advancements of nanotechnology.

Author: Deepak Chitkara

Publisher: CRC Press

ISBN: 9781351978378

Category: Medical

Page: 610

View: 869

DOWNLOAD & READ
The field of molecular medicine covers the medical interventions targeting molecular structures and mechanisms that are involved in disease progression. In cancer, several molecular mechanisms have been shown to impact its progression, aggressiveness and chemoresistance. Increasing evidence demonstrates the role of nanotechnology and outcome of molecular therapy. Several books have discussed molecular biology and mechanisms involved in cancer, but this text gives an account of molecular therapeutics in cancer relating to advancements of nanotechnology. It provides a description of the multidisciplinary field of molecular medicines and its targeted delivery to cancer using nanotechnology. Key Features: Provides current information in the multidisciplinary field of molecular medicines and its targeted delivery to cancer using nanotechnology Presents important aspects of nanotechnology in the site-specific delivery of anticancer agents Includes up to date information on oligonucleotide and gene based therapies in cancer Describes small targeted molecules, antibodies and oligonucleotides which have shown to selectively target the molecular structures thereby influencing signal transduction Facilitates discussion between researchers involved in cancer therapy and nanoscientists
2018-09-03 By Deepak Chitkara

This book targets a wide audience: a broad introduction provides a solid academic background for students, researchers, and scientists who are unfamiliar with the subject, while the in-depth descriptions and discussions are useful for ...

Author: John Maclane

Publisher: Createspace Independent Publishing Platform

ISBN: 1548041254

Category:

Page: 446

View: 908

DOWNLOAD & READ
In the past few decades there has been incredible growth in "bionano"-related research, which has been accompanied by numerous publications in this field. Although various compilations address topics related to deoxyribonucleic acid (DNA) and protein, there are few books that focus on determining the structure of ribonucleic acid (RNA) and using RNA as building blocks to construct nanoarchitectures for biomedical and healthcare applications. RNA Nanotechnology is a comprehensive volume that details both the traditional approaches and the latest developments in the field of RNA-related technology. This book targets a wide audience: a broad introduction provides a solid academic background for students, researchers, and scientists who are unfamiliar with the subject, while the in-depth descriptions and discussions are useful for advanced professionals. The book opens with reviews on the basic aspects of RNA biology, computational approaches for predicting RNA structures, and traditional and emerging experimental approaches for probing RNA structures. This section is followed by explorations of the latest research and discoveries in RNA nanotechnology, including the design and construction of RNA-based nanostructures. The final segment of the book includes descriptions and discussions of the potential biological and therapeutic applications of small RNA molecules, such as small/short interfering RNAs (siRNAs), microRNAs (miRNAs), RNA aptamers, and ribozymes.
2017-06-07 By John Maclane

The book introduces the basic concepts of nanotechnology and the various technologies to characterize nanomaterials. It also covers the nanostructural features of mammalian cells/tissues and related nanomechanical properties.

Author: Sanjay Singh

Publisher: Springer

ISBN: 9789811360046

Category: Medical

Page: 254

View: 854

DOWNLOAD & READ
The book introduces the basic concepts of nanotechnology and the various technologies to characterize nanomaterials. It also covers the nanostructural features of mammalian cells/tissues and related nanomechanical properties. In addition, the book comprehensively describes the current state-of-the-art and future perspectives of nanotechnology in biosensors. It also discusses the potential of nanotechnology for delivering the diverse cancer therapeutics and illustrates its limitation due to the potential toxicity associated with oxidative stress. It also highlights the ethical issues and translational aspects related to nanotechnology. Finally, it summarizes the applications of nanotechnology in animal biotechnology, the recent perspectives and future challenges of nanomedicines. The content of the book are beneficial for the undergraduate, postgraduate and doctoral students as well the professionals working in the area of nanotechnology and nanomedicines.
2019-03-30 By Sanjay Singh

Original reviews are presented on a variety of topics relating to the rapidly developing intersection between nanotechnology and cancer research, with unique sections in the new release focusing on Exosomes as a theranostic for lung cancer, ...

Author:

Publisher: Academic Press

ISBN: 9780128141700

Category: Medical

Page: 222

View: 374

DOWNLOAD & READ
Advances in Cancer Research, Volume 139, provides invaluable information on the exciting and fast-moving field of cancer research. Original reviews are presented on a variety of topics relating to the rapidly developing intersection between nanotechnology and cancer research, with unique sections in the new release focusing on Exosomes as a theranostic for lung cancer, Nanotechnology and cancer immunotherapy, Ultrasound imaging agents and delivery systems, Dendronized systems for the delivery of chemotherapeutics, Thermosensitive liposomes for image-guided drug delivery, Supramolecular Chemistry in Tumor Analysis and Drug Delivery, Gold nanoparticles for delivery of cancer therapeutics, and Single cell barcode microchip for cancer research and therapy. Provides the latest information on cancer research Offers outstanding and original reviews on a range of cancer research topics Serves as an indispensable reference for researchers and students alike
2018-06-23 By

This book targets a wide audience: a broad introduction provides a solid academic background for students, researchers, and scientists who are unfamiliar with the subject, while the in-depth descriptions and discussions are useful for ...

Author: Bin Wang

Publisher:

ISBN: OCLC:880420915

Category:

Page:

View: 515

DOWNLOAD & READ
In the past few decades there has been incredible growth in "bionano"--Related research, which has been accompanied by numerous publications in this field. Although various compilations address topics related to deoxyribonucleic acid (DNA) and protein, there are few books that focus on determining the structure of ribonucleic acid (RNA) and using RNA as building blocks to construct nanoarchitectures for biomedical and healthcare applications. RNA Nanotechnology is a comprehensive volume that details both the traditional approaches and the latest developments in the field of RNA-related technology. This book targets a wide audience: a broad introduction provides a solid academic background for students, researchers, and scientists who are unfamiliar with the subject, while the in-depth descriptions and discussions are useful for advanced professionals. The book opens with reviews on the basic aspects of RNA biology, computational approaches for predicting RNA structures, and traditional and emerging experimental approaches for probing RNA structures. This section is followed by explorations of the latest research and discoveries in RNA nanotechnology, including the design and construction of RNA-based nanostructures. The final segment of the book includes descriptions and discussions of the potential biological and therapeutic applications of small RNA molecules, such as small/short interfering RNAs (siRNAs), microRNAs (miRNAs), RNA aptamers, and ribozymes.
2014 By Bin Wang

The chapters in this book cover a range of strategies for molecular and cellular therapies for human disease, their advantages, and central challenges to their widespread application.

Author: Giridhara R. Jayandharan

Publisher: Springer

ISBN: 9789811304811

Category: Medical

Page: 305

View: 139

DOWNLOAD & READ
Recent advances in stem cell biology, nanotechnology and gene therapy have opened new avenues for therapeutics. The availability of molecular therapeutics that rely on the delivery of DNA, RNA or proteins, harnessing enhanced delivery with nanoparticles, and the regenerative potential of stem cells (adult, embryonic or induced pluripotent stem cells) has had a tremendous impact on translational medicine. The chapters in this book cover a range of strategies for molecular and cellular therapies for human disease, their advantages, and central challenges to their widespread application. Potential solutions to these issues are also discussed in detail. Further, the book addresses numerous advances in the field of molecular therapeutics that will be of interest to the general scientific community. Lastly, the book provides specific examples of disease conditions for which these strategies have been transferred to the clinic. As such, it will be extremely useful for all students, researchers and clinicians working in the field of translational medicine and molecular therapeutics.
2018-09-12 By Giridhara R. Jayandharan

This book is intended to provide comprehensive, most up-to-date information on the history and recent advancement of ER and breast cancer by world renowned leaders in the field.

Author: Xiaoting Zhang

Publisher: Springer

ISBN: 9783319993508

Category: Medical

Page: 417

View: 715

DOWNLOAD & READ
The discovery of ER by Dr. Elwood Jensen exactly 60 years ago has not only led to the birth of a whole new vital nuclear receptor research field but also made a rapid, direct and lasting impact on the treatment and prevention of breast cancer. Since that landmark discovery, tremendous progress has been made in our understanding of the molecular functions of ER and development of targeted therapies against ER pathways for breast cancer treatment. However, there is currently no book available addressing these discoveries and recent advancement in a historical and systematic fashion. This book is intended to provide comprehensive, most up-to-date information on the history and recent advancement of ER and breast cancer by world renowned leaders in the field. These chapters include the history of the discovery of ER; physiological and pathological roles of ER; recent discovery of ER cistrome, transcriptome and its regulation of noncoding RNAs such as microRNAs and enhancer RNAs in breast cancer; development and clinical practices of the first targeted therapy Tamoxifen and other antiestrogens for breast cancer treatment; structural basis of ER and antiestrogen actions; molecular insights into endocrine resistance; the role of ER mutants, ER-beta and environmental estrogens in breast cancer; and emerging state-of-the-art therapeutic approaches currently in development to overcome treatment resistance and future perspectives. The book will provide undergraduate and graduate students, basic scientists and clinical cancer researchers, residents, fellows, as well as clinicians, oncology educators and the general public a thorough and authoritative review of these exciting topics.
2018-10-16 By Xiaoting Zhang

Best Books