Search Results for introduction-to-translational-cancer-research

An Introduction to Translational Cancer Research provides a brief overview of current understanding of human cancer biology that is driving interests in targeted therapy and personalized management. Further development of molecular ...

Author: Apostolia-Maria Tsimberidou

Publisher: John Wiley & Sons

ISBN: 9781118468579

Category: Medical

Page: 400

View: 229

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Translational medicine has opened the gateway to the era of personalized medicine. No longer a one-size-fits-all approach, the treatment of cancer is now based on an understanding of underlying biologic mechanisms and is increasingly being tailored to the molecular specificity of a tumor. Translational Oncology: Targeted Therapy in Translational Cancer Research provides a comprehensive overview of the pertinent molecular discoveries in the cancer field and explains the clinical ramifications and utility of these on targeted cancer therapies. Beginning with a chapter introducing the “Bench to Bedside and Back” paradigm, an overview is presented of the exponential growth in the field of translational medicine, including historical perspectives and recent progress. Following the introduction, subsequent chapters review the progress of targeted therapy within three major categories: hematological malignancies, solid tumors, and hereditary cancers. Each of these categories comprises a single a chapter with subsections that discuss specific cancer types. Following this is a chapter on targeted and functional imaging that reviews progress in the different modalities of anatomical and molecular imaging used to complement targeted therapy. The next chapter discusses the need to combine individual agents with existing therapies or in novel combinations in order to overcome drug resistance. Following this is a chapter presenting the challenges in drug development and the selection of targets for cancer therapeutics. The final chapter offers perspectives on personalized medicine and presents future challenges in the investigation of optimal combinations and the identification of biomarkers that can provide both predictive and prognostic information for tailoring targeted therapies to individual patients.

The first comprehensive primer of its kind for translational cancer research, this book features robust discussion of the latest in human cancer biology, and the heterogeneity of cancers at a molecular level, including highly sophisticated ...

Author: Robert C. Bast

Publisher: Wiley-Blackwell

ISBN: 0470627522

Category: Medical

Page: 384

View: 240

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The first comprehensive primer of its kind for translational cancer research, this book features robust discussion of the latest in human cancer biology, and the heterogeneity of cancers at a molecular level, including highly sophisticated characterization of human cancers, bioinformatics, and systems biology. Written by renowned authors all based at the world-famous M.D. Anderson Cancer Center, this book is specifically designed for physicians, clinical fellows, medical students, graduate students, and those eager to speed the progress in clinical cancer care by enhancing the bidirectional interaction between laboratory and clinic.
2016-05-31 By Robert C. Bast

Introduction. We live and work in the age of immunotherapy. The modality is now firmly affixed to the triad of chemotherapy, radiation therapy, and surgery. This book captures the translation of immunology into therapies.

Author: Laurence J. N. Cooper

Publisher: John Wiley & Sons

ISBN: 9781118123225

Category: Medical

Page: 312

View: 290

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A guide to state-of-the-art cancer immunotherapy in translational cancer research A volume in the Translational Oncology series, Immunotherapy in Translational Cancer Research explores the recent developments in the role that immunotherapy plays in the treatment of a wide range of cancers. The editors present key concepts, illustrative examples, and suggest alternative strategies in order to achieve individualized targeted therapy. Comprehensive in scope, Immunotherapy in Translational Cancer Research reviews the relevant history, current state, and the future of burgeoning cancer-fighting therapies. The book also includes critical information on drug development, clinical trials, and governmental resources and regulatory issues. Each chapter is created to feature: development of the immunotherapy; challenges that have been overcome in order to scale up and undertake clinical trials; and clinical experience and application of research. This authoritative volume is edited by a team of noted experts from MD Anderson Cancer Center, the world’s foremost cancer research and care center and: Offers a comprehensive presentation of state-of-the-art cancer immunotherapy research that accelerates the pace of clinical cancer care Filled with the concepts, examples, and approaches for developing individualized therapy Explores the breath of treatments that reflect the complexity of the immune system itself Includes contributions from a panel international experts in the field of immunotherapy Designed for physicians, medical students, scientists, pharmaceutical executives, public health and public policy government leaders and community oncologists, this essential resource offers a guide to the bidirectional interaction between laboratory and clinic immunotherapy cancer research.
2018-05-01 By Laurence J. N. Cooper

Translational Research in Endocrine Surgery Scott K. Sherman, MD, James R. Howe, MD* KEYWORDS Endocrine cancer Heritable cancer ... INTRODUCTION The past 30 years have seen astounding advances in the science of endocrine sur- gery.

Author: William G. Cance

Publisher: Elsevier Health Sciences

ISBN: 9780323227452

Category: Medical

Page: 311

View: 395

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This issue of the Surgical Oncology Clinics of North America, Guest Edited by Dr. William G. Cance, is devoted to Translational Cancer Research for Surgeons. Translational Cancer research aims to move bench research to the bedside by applying basic science toward potential therapies. This issue will present the concepts of translational research and development of targeted therapeutics, and its implications for surgeons. It will show clinical applications for surgeons regarding sarcoma/GIST, melanoma, colorectal cancer, breast cancer, and endocrine cancer.
2013-09-11 By William G. Cance

Translational Research in Endocrine Surgery Scott K. Sherman, MD, James R. Howe, MD* KEYWORDS Endocrine cancer Heritable cancer ... INTRODUCTION The past 30 years have seen astounding advances in the science of endocrine sur- gery.

Author: William G. Cance

Publisher: Elsevier Health Sciences

ISBN: 9780323227445

Category: Medical

Page: 16

View: 239

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This issue of the Surgical Oncology Clinics of North America, Guest Edited by Dr. William G. Cance, is devoted to Translational Cancer Research for Surgeons. Translational Cancer research aims to move bench research to the bedside by applying basic science toward potential therapies. This issue will present the concepts of translational research and development of targeted therapeutics, and its implications for surgeons. It will show clinical applications for surgeons regarding sarcoma/GIST, melanoma, colorectal cancer, breast cancer, and endocrine cancer.
2013-01-01 By William G. Cance

This book presents concise chapters written by internationally respected experts on various important aspects of translational cancer genomics, offering a comprehensive overview of the onco-omics applications in the new era of cancer ...

Author: Erika Ruiz-Garcia

Publisher: Springer Nature

ISBN: 9783030241001

Category: Science

Page: 171

View: 988

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Being a complex disease that affects millions of people world over, cancer research has assumed great significance. Translational cancer research transforms scientific discoveries in the laboratory into clinical application to reduce incidence of cancer, morbidity and mortality. On the other hand, personalized medicine in cancer is the concept that selection of a treatment should be tailored according to the individual patient’s specific genomic characteristics, including mutations, chromosomal aberrations, protein interactions, and SNPs, and even more, taking into account the inmume system, the metabolism and maybe in the next future also the microbiome.
2019-11-11 By Erika Ruiz-Garcia

SFN has been shown to exhibit cytostatic and cytotoxic activities against a number of cancer cell types in vitro and ... Chemoprevention • 4-Hydroxynonenal • Lipid peroxidation 8.1 Introduction Cancer leads to immense human suffering as ...

Author: Perumana R. Sudhakaran

Publisher: Springer Science & Business Media

ISBN: 9788132215332

Category: Medical

Page: 168

View: 921

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Being a complex disease that affects millions of people world over, cancer research has assumed great significance. Translational cancer research transforms scientific discoveries in the laboratory or population studies into clinical application to reduce incidence of cancer , morbidity and mortality. It is becoming increasingly evident that cancer is a preventable disease. The IVth International Symposium on Translational Cancer Research held in Udaipur, India in December 2011, discussed various aspects of the biological processes in cancer cells and approaches to cancer prevention. A few contributions from this meeting are presented in this book, providing an in depth analysis of data on cancer prevention and therapeutics. These contributions are either critical reviews or research reports. The topics discussed include evidence-based nutritional recommendations for cancer patients and survivors, risk factors such as stress, enrichment of tumour stem cells by anticancer drug treatment contributing to tumour recurrence and the mechanism of anticancer effects of various natural products. Chemosensitizing effect of curcumin, anti-cancer effect of products from neem, action of sulforaphane and cytotoxic effect of a number of novel synthetic coordination complexes of trace metals have been discussed. Novel molecular targets of angiogenesis and molecular basis of the gender bias to thyroid cancer have also been discussed . This book provides useful information on translational cancer research to clinicians and biomedical scientists.
2013-10-25 By Perumana R. Sudhakaran

There were three main aims of the NCRI: (i) to take a strategic overview of cancer research in the UK; (ii) to identify gaps ... The aim of the National Translational Cancer Research Network (NTRAC), the sister organisation of the NCRI, ...

Author: Imran Rafi

Publisher: Elsevier Health Sciences

ISBN: 9780750688307

Category: Medical

Page: 209

View: 685

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This title is directed primarily towards health care professionals outside of the United States. The aim of this book is to provide an introduction to the principles of drug treatment for solid tumours in cancer medicine. Developments in the understanding of tumour biology, molecular biology and genetics - together with the greater understanding of the pharmacology and pharmacokinetics of drugs - have combined to open up the field of medical oncology to rapid advances in the treatment of cancers. The range of drugs that are available is wide and one of the primary aims in drug development is to increase the therapeutic window so that drug toxicity is minimised and tolerable. Drug development of oral formulations of anticancer drugs and the use of drugs that could be given in the day patient setting means that healthcare professionals such as general practitioners - who historically might not have been involved in the drug treatment of the cancer patient - are now going to need to have a greater understanding of the principles of use of anticancer drugs. This book is primarily aimed at this market. Basic principles of drug treatment - develops an understanding of why and when anticancer drugs are used. Covers the purpose of clinical trials in oncology from Phase I to Phase IV trials in drug development. Discusses the organisation of clinical networks in the UK. Case studies in cancer treatment, allowing an understanding of when and why the typical regimes are used. NICE guidelines.
2006 By Imran Rafi

We employ a semantic content network approach to address the challenges of managing cancer research data. ... Introduction. Translational cancer research builds on incorporating multiple levels of biological information within clinical ...

Author: Panayiotis Vlamos

Publisher: Springer

ISBN: 9783319090122

Category: Medical

Page: 240

View: 593

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The 1st World Congress on Geriatrics and Neurodegenerative Disease Research (GeNeDis 2014), will focus on recent advances in geriatrics and neurodegeneration, ranging from basic science to clinical and pharmaceutical developments and will provide an international forum for the latest scientific discoveries, medical practices and care initiatives. Advanced information technologies will be discussed concerning the various research, implementation and policy, as well as European and global issues in the funding of long-term care and medico-social policies regarding elderly people. GeNeDis 2014 takes place in Corfu Greece, 10-13 April 2014. This volume focuses on the sessions from the conference on computational biology and bioinformatics.
2014-11-22 By Panayiotis Vlamos

INTRODUCTION Since 1992, the Specialized Programs of Research Excellence (SPOREs) has been the U.S. National Cancer Institute's premier translational cancer research grants program. SPOREs support multi-project, interdisciplinary ...

Author: Rakesh Srivastava

Publisher: World Scientific

ISBN: 9789814489089

Category: Medical

Page: 768

View: 845

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This book is all about the definition and finding ways to prioritize and accelerate translation research in biomedical sciences and rapidly turning new knowledge into first-in-human studies. It represents an effort to bring together scientists active in various areas of translational research to share science and, hopefully, generate new ideas and potential collaborations. The book provides a comprehensive overview of translational work that includes significant discoveries and pioneering contributions, e.g., in immunology, gene therapy, stem cells and population sciences. It may be used as an advanced textbook by graduate students and even ambitious undergraduates in biomedical sciences. It is also suitable for non-experts, i.e. medical doctors, who wish to have an overview of some of the fundamental models in translational research. Managing the translational enterprise remains a work in progress. The world is changing rapidly, and the scientific world needs to seek new ways to ensure that discoveries get translated for patients efficiently and as quickly as possible. In addition, everyone expects the investment in biomedical research should pay dividends through effective therapeutic solutions. This unique project provides a broad collaborative approach of the international scientific team to present its view and opinion how to cross barriers to incentives for translational research in medical sciences. Contributing to the book is an international team of prominent co-authors. The book consists of unique and widely treated topics, and includes new hypotheses, data and analyses. Contents:Barriers to Incentives for Translational ResearchIntegrating Emerging Science into Clinical PracticeOrganization, Prioritization, Review and Funding for the Translational ResearchTranslational Sciences in Cancer ResearchTranslational Science in Infectious DiseasesTranslation Research in Endocrinology and NutritionTranslation Research and NeuroscienceStem Cells and Translation ResearchThe Role of Translational Research in Public Health and Behavioral SciencesTranslational Epidemiology, Biostatistics and InformaticsTranslational Research Outcomes and Resources Readership: Graduate students and researchers in cancer research, pharmacology/drug discovery/pharmaceuticals, immunology, infectious diseases and public health. Keywords:Translational Research;Basic and Clinical Sciences;Prevention;Population SciencesKey Features:International team of prominent co-authorsUnique and widely treated topicsNew hypotheses, data and analyses
2014-03-14 By Rakesh Srivastava