Search Results for drug-design-research-perspectives

Unfortunately , they displayed poor response in clinical studies . Recently , new compounds obtained from drug development programs conducted by the pharmaceutical industry are characterized by a high affinity to MDR transporters and ...

Author: Liman S. Torres

Publisher: Nova Publishers

ISBN: 1600215726

Category: Medical

Page: 223

View: 439

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One of the main causes of failure in the treatment of cancer is the development of drug resistance by the cancer cells. The design of cancer chemotherapy has become increasingly sophisticated, yet there is no cancer treatment that is 100% effective against disseminated cancer. Resistance to treatment with anticancer drugs results from a variety of factors including individual variations in patients and somatic cell genetic differences in tumours, even those from the same tissue of origin. Frequently resistance is intrinsic to the cancer, but as therapy becomes more and more effective, acquired resistance has also become common. The most common reason for acquisition of resistance to a broad range of anticancer drugs is expression of one or more energy-dependent transporters that detect and eject anticancer drugs from cells, but other mechanisms of resistance including insensitivity to drug-induced apoptosis and induction of drug-detoxifying mechanisms probably play an important role in acquired anticancer drug resistance. Studies on mechanisms of cancer drug resistance have yielded important information about how to circumvent this resistance to improve cancer chemotherapy and have implications for pharmacokinetics of many commonly used drugs. This book presents new and important research in this field.
2007 By Liman S. Torres

These inclusive perspectives contribute to the available knowledge on health promotion through nutraceuticals. Section 4, “Molecular Modeling and Drug Design,” discusses coverage and research perspectives on innovative approaches to ...

Author: Management Association, Information Resources

Publisher: IGI Global

ISBN: 9781522517634

Category: Medical

Page: 1584

View: 868

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The delivery of optimal pharmaceutical services to patients is a pivotal concern in the healthcare field. By examining current trends and techniques in the industry, processes can be maintained and improved. Pharmaceutical Sciences: Breakthroughs in Research and Practice provides comprehensive coverage of the latest innovations and advancements for pharmaceutical applications. Focusing on emerging drug development techniques and drug delivery for improved health outcomes, this book is ideally designed for medical professionals, pharmacists, researchers, academics, and upper-level students within the growing pharmaceutical industry.

[ 158 ] Gedda , L .; Ghaneolhosseini , H .; Nilsson , P .; Nyholm , K .; Pettersson , J .; Sjöberg , S .; Carlsson , J. Anti - Cancer Drug Design . 2000 , 15 , 277-286 . [ 159 ] Kelly , D. P .; Bateman , S. A .; Martin , R. E .

Author: Richard P. Irwin

Publisher: Nova Publishers

ISBN: 160021780X

Category: Science

Page: 309

View: 920

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Organometallic chemistry is based on the reactions and use of a class of compounds (R-M) that contain a covalent bond between carbon and metal. They are prepared either by direct reaction of the metal with an organic compound or by replacement of a metal from another organometallic substance. This book presents research in this field.

... Drug Design, Predictive Toxicology, and Risk Assessment Kunal Roy (Jadavpur University, India) Medical Information Science Reference • copyright 2015 • 703pp• H/C (ISBN: 9781466681361) • US $295.00 (our price) Handbook of Research ...

Author: Zuzuarregui, Ana

Publisher: IGI Global

ISBN: 9781522500674

Category: Technology & Engineering

Page: 511

View: 591

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Just as chemistry is a part of our daily lives, functional coatings can be found in almost every object, gadget or device you can see or touch. However, in the last 20 years the advances made in the preparation of different functional coatings with diverse compositions have allowed the development of nanoscale coatings that are more cost-effective and environmentally conscious than traditional coatings. Research Perspectives on Functional Micro- and Nanoscale Coatings highlights critical research on preparation methods, modification, organization, and utilization of functional coatings in micro, nano, and biotechnology. Emphasizing emerging developments and global research perspectives, this publication is a pivotal resource for engineers, researchers, and graduate-level students interested in learning about emerging developments in functional coatings and nanotechnology.
2016-04-11 By Zuzuarregui, Ana

From the perspective of the reforms during the period 2014– 2015, the central decision-makers of the medical reform ... In terms of drug expenditure control, the National Development and Reform Commission and six other departments ...

Author: Peilin LI

Publisher: BRILL

ISBN: 9789004418622

Category: Social Science

Page: 442

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2019-11-11 By Peilin LI

ket, which may reflect a diminished research effort in antibiotics five, 10, and more years ago. Currently, there is a great deal of ... A perspective of modern methods in computer-aided drug design. Comprehensive Reviews Chemistry ...

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Publisher: DIANE Publishing

ISBN: 9781428920255

Category:

Page:

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DEVELOPMENT Merck & Company, Kenilworth: Fluorescence-based thermal shift assays A new study, 'Fluorescence-based ... a pharmaceutical research perspective Research findings, 'Metabolic bioactivation and drug-related adverse effects: ...

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Publisher: ScholarlyEditions

ISBN: 9781464963421

Category: Medical

Page: 4229

View: 295

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Issues in Pharmacology, Pharmacy, Drug Research, and Drug Innovation: 2011 Edition is a ScholarlyEditions™ eBook that delivers timely, authoritative, and comprehensive information about Pharmacology, Pharmacy, Drug Research, and Drug Innovation. The editors have built Issues in Pharmacology, Pharmacy, Drug Research, and Drug Innovation: 2011 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Pharmacology, Pharmacy, Drug Research, and Drug Innovation in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Issues in Pharmacology, Pharmacy, Drug Research, and Drug Innovation: 2011 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.
2012-01-09 By

Supercomputing and drug discovery research . Perspectives Drug Discovery and Design 1 : 345-348 . Bristol - Meyers Squibb . 1995. The “ Hand - Offs ” at Bristol - Myers Squibb . Biotechnology Industry Advertising Supplement .

Author: United States Government Printing Office

Publisher: U.S. Government Printing Office

ISBN: MINN:31951P009823163

Category: Antibacterial agents

Page: 183

View: 107

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Click chemistry in carbohydrate based drug development and glycobiology. In: Kaplan, S.P. (Ed.), Drug Design Research Perspectives. Nova Science Publishers, New York, pp. 57–102. Wilson, J.C., Kiefel, M.J., von Itzstein, M., 2005.

Author: Anthony P Moran

Publisher: Elsevier

ISBN: 0080923240

Category: Science

Page: 1036

View: 112

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This book presents in an easy-to-read format a summary of the important central aspects of microbial glycobiology, i.e. the study of carbohydrates as related to the biology of microorganisms. Microbial glycobiology represents a multidisciplinary and emerging area with implications for a range of basic and applied research fields, as well as having industrial, medical and biotechnological implications. Individual chapters provided by leading international scientists in the field yield insightful, concise and stimulating reviews Provides researchers with an overview and synthesis of the latest research Each chapter begins with a brief 200 word Summary/Abstract detailing the topic and focus of the chapter, as well as the concepts to be addressed Allows researchers to see at a glance what each chapter will cover Each chapter includes a Research Focus Box Identifies important problems that still need to be solved and areas that require further investigation
2009-10-01 By Anthony P Moran

ComputerAided. Drug. Design. in. Industry: A. Summary. of. Perspectives. R. FrankeandE.C.Herrmann Based on the discussions and, in particular, a general discussion held at the endofthe workshop this final chapter summarizes questions, ...

Author: E.C. Herrmann

Publisher: Springer Science & Business Media

ISBN: 9783662031414

Category: Science

Page: 254

View: 351

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The Ernst Schering Research Foundation sponsored its 15th workshop in Berlin on October 19-21, 1994. Leading scientists from Europe and North America were invited to discuss computer-aided drug design in industrial research. Computer-aided drug design is a very exciting field and an intellec tual challenge, like playing chess. But these reasons are no longer suf ficient to justify using this method in industry, if they ever were. Fig. 1. The participants of the workshop VI Preface Therefore, when we, together with Prof. Hoyer, started to think about this workshop, our intentions quickly became clear. We were not so much interested in the very latest developments of methods or in computer-aided drug design itself - enough conferences have dealt with these topics. However, we were very interested in the usefulness and limitations of computer-aided drug design in the indu strial research process. A lot has changed in the pharmaceutical industry recently. These changes are gaining momentum, so it is the right time to think about the role of computer-aided drug design in this changing environment.
2013-03-09 By E.C. Herrmann

Novel dual inhibitors of nuclear factorkappa B (NFκB) and cyclooxygenase2 (COX2): synthesis, in vitro anticancer activity and stability studies of lantadenenon steroidal antiinflammatory drug (NSAID) conjugates, Curr Top Med Chem 14, ...

Author: Girish Kumar Gupta

Publisher: Walter de Gruyter GmbH & Co KG

ISBN: 9783110392692

Category: Science

Page: 297

View: 385

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Chemical Drug Design provides a compact overview on recent advances in this rapidly developing field. With contributions on in silico drug design, natural product based compounds, as well as on ligand- and structure-based approaches, the authors present innovative methods and techniques for identifying and synthetically designing novel drugs.
2016-10-10 By Girish Kumar Gupta

(2010 MAR 1) University of Milan, Milano: Structure and functionality in flavivirus NSproteins: perspectives for drug design Research findings, 'Structure and functionality in flavivirus NSproteins: perspectives for drug design,' are ...

Author:

Publisher: ScholarlyEditions

ISBN: 9781464912078

Category: Medical

Page: 22

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Flavivirus: New Insights for the Healthcare Professional: 2011 Edition is a ScholarlyPaper™ that delivers timely, authoritative, and intensively focused information about Flavivirus in a compact format. The editors have built Flavivirus: New Insights for the Healthcare Professional: 2011 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Flavivirus in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Flavivirus: New Insights for the Healthcare Professional: 2011 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.
2012-01-09 By

Optimal control of drug epidemics : Prevent and treatBut not at the same time . Management Science , 46 ( 3 ) , 333–347 ... Ecology of the family as a context for human development : Research perspectives . Developmental Psychology , 22 ...

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Publisher:

ISBN: PURD:32754077066896

Category: Drug abuse

Page: 201

View: 715

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For criminal justice practitioners who deal with drugs and crime day in and day out, the reality of the drugs-crime nexus is indisputable. In a manual designed to help police chiefs and sheriffs control drug abuse, the International Association of Chiefs of Police (IACP) stated unequivocally its belief in?a significant though complex? relationship between drug abusers and criminal offenders. Change one group, IACP proposed, and you change the other:?If there is a reduction in the number of people who abuse drugs in your community, there will be a reduction in the commission of certain types of crime in your community.?
2003 By

Investigators discuss in “AGGRESCAN: method, application, and perspectives for drug design” new findings in Drug Development. According to the authors of recent research published in the journal Methods In Molecular Biology, ...

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Publisher: ScholarlyEditions

ISBN: 9781464990892

Category: Medical

Page: 1193

View: 539

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Drugs—Advances in Research and Application / 2012 Edition is a ScholarlyEditions™ eBook that delivers timely, authoritative, and comprehensive information about Drugs. The editors have built Drugs—Advances in Research and Application: 2012 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Drugs in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Drugs—Advances in Research and Application: 2012 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.
2012-12-26 By

In G. Deka, G. Siddesh, K. Srinivasa, & L.Patnaik (Eds.), Emerging Research Surrounding Power Consumption and Performance Issues in Utility Computing (pp. ... Role of Molecular Docking in ComputerAided Drug Design and Development.

Author: Marzullo, Fabio Perez

Publisher: IGI Global

ISBN: 9781799850229

Category: Education

Page: 252

View: 419

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The video game market continues to increase, reaching millions of users on a variety of platforms and revealing how engaging and pervasive gaming can be. Games create engagement and offer both entertainment and a powerful way to understand and interact with the world. It is natural that educators see the potential of games as a learning tool that can support students who have difficulties learning and also reinvent it. Practical Perspectives on Educational Theory and Game Development is a critical scholarly resource that combines educational scenarios and game fundamentals in order to improve the way people learn and evolve. The book supports professionals with the creation of strategies for using gamification and game-based learning theory with effectiveness and measured results. Featuring a wide range of topics such as entrepreneurship, gamification, and traditional learning, this book is ideal for academicians, education professionals, curriculum designers, educational game developers, researchers, and students.
2021-06-25 By Marzullo, Fabio Perez

To illustrate, the Food and Drug Administration (FDA) approved for the first time a drug aimed specifically at a racial group in the spring of 2005. In the rationale for the drug's development, and in the lead-up to the nature and ...

Author: Howard Lune

Publisher: SAGE

ISBN: 9781412967396

Category: Social Science

Page: 445

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This book shows students the steps involved in the research process, the various strategies for conducting a valid social inquiry, and most importantly, the persuasiveness and elegance of reliable social research. It highlights the link between academic research and the real world. Included are carefully chosen examples of each of the major methodological techniques-survey, interviews, fieldwork observations, experiments, content analysis, secondary analysis and program evaluation. Also included are selections on sampling strategies, research ethics and both qualitative and quantitative data analysis.
2010 By Howard Lune

Biodiversity prospering and benefit-sharing: perspectives from the field.J Ethnopharmacol 1996;51:1-15. 2. Claeson P, Bohlin L. Some aspects of bioassay methods in natural-product research aimed at drug lead discovery.

Author: David A. Williams

Publisher: Lippincott Williams & Wilkins

ISBN: 9780683307375

Category: Medical

Page: 1114

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This comprehensive Fifth Edition has been fully revised and updated to meet the changing curricula of medicinal chemistry courses. The new emphasis is on pharmaceutical care that focuses on the patient, and on the pharmacist a therapeutic clinical consultant, rather than chemist. Approximately 45 contributors, respected in the field of pharmacy education, augment this exhaustive reference. New to this edition are chapters with standardized formats and features, such as Case Studies, Therapeutic Actions, Drug Interactions, and more. Over 700 illustrations supplement this must-have resource.
2002-01 By David A. Williams

Stereoselective synthesis from a process research perspective. Drug Discov Today 7, 303–314. Ho ̈ll, V., Kouba, M., Dietel, M., and Vogt, G. (1992). Stereoisomers of calcium antagonists which differ markedly in their potencies as ...

Author: Ziwei Huang

Publisher: John Wiley & Sons

ISBN: 0470131853

Category: Science

Page: 464

View: 154

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Post Genomics Drug Discovery and Research explores and discusses some of the most important topics in post-genomics life and biopharmaceutical sciences. It provides an introduction to the field, outlining examples of many techniques currently used, as well as those still under development, which are important for the research of biopharmaceutical discovery in the post-genomics era. Integrates several developing and cutting-edge technologies and methods like bioinformatics, experimental therapeutics, and molecular recognition Includes discussion on topics such as: computer-aided ligand design; peptide and protein chemistry and synthesis; synthesis of active natural products; and the use of emerging technologies like proteomics, nanotechnology, or bioengineering.
2007-06-11 By Ziwei Huang

DEVELOPMENT Wilson-Sanchez and colleagues published their study in Marine Drugs (Antimutagenicity and antiproliferative ... According to recent research published in the journal Drug News and Perspectives, “For the last two decades, ...

Author:

Publisher: ScholarlyEditions

ISBN: 9781481645621

Category: Medical

Page: 617

View: 969

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Issues in Pharmacology, Pharmacy, Drug Research, and Drug Innovation: 2012 Edition is a ScholarlyEditions™ eBook that delivers timely, authoritative, and comprehensive information about Molecular Pharmacology. The editors have built Issues in Pharmacology, Pharmacy, Drug Research, and Drug Innovation: 2012 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Molecular Pharmacology in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Issues in Pharmacology, Pharmacy, Drug Research, and Drug Innovation: 2012 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.
2013-01-10 By

... what has been called the ' biotechnological revolution ' reflects the perception that drug development has entered a ... from the perspective of its top research management , and focus specifically on drug development strategies .

Author: Viviane Quirke

Publisher: Peter Lang

ISBN: 3039109200

Category: Medical

Page: 483

View: 237

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One of the most striking features of the twentieth century has been the rapid growth of the pharmaceutical industry and the large increases in the use and consumption of its products. This trend began in the first half of the century, but accelerated most sharply after the Second World War, when the creation of national systems of healthcare created mass markets for drugs. The industry then assumed a major economic, social and political significance, and became one of the most highly regulated sectors of the economy, attracting the attention of industry analysts as well as academics. This volume brings together a collection of papers exploring and reflecting upon some of the significant strands in the current studies of pharmaceuticals in the twentieth century. They touch upon many of the issues that are matters of concern and debate today, and their international and multidisciplinary approaches enrich our understanding of an object, of an industry, and of a process that are at the heart of our highly medicalized contemporary societies.
2010 By Viviane Quirke

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