Search Results for current-advances-in-osteosarcoma

This volume will ​provide a comprehensive review of these new discoveries in one singular text, which will help move the field forward.

Author: Eugenie S. Kleinerman, M.D.

Publisher: Springer

ISBN: 9783319048437

Category: Medical

Page: 359

View: 578

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Current Advances in Osteosarcoma edited by Dr. Eugenie S. Kleinerman summarizes molecular and genetic characteristics, new therapeutic ideas, and biological characteristics that have been uncovered in the past 10 years. Osteosarcoma is an aggressive malignant neoplasm and it is also the most common histological form of bone cancer. It accounts for approximately 56% of new bone tumors, making it the most primary malignant bone tumor in children and adolescents. The lungs are the most common site of metastases and once osteosarcoma spreads to the lungs, it is very difficult to treat. To improve the outcome of this disease, the biology of osteosarcoma needs to be better understood. There are numerous investigators around the world who have made seminal discoveries about the important molecular pathways and genetic alterations that contribute to the development and metastases of osteosarcoma. Other investigators have proposed novel therapeutic strategies including some based on the molecular and genetic phenotype of the disease. Current Advances in Osteosarcoma summarizes all of these new discoveries in one singular text, which will help move the field forward.

Correction to: Current Advances in Osteosarcoma Eugenie S. Kleinerman and Richard Gorlick Correction to: Part IV in: E. S. Kleinerman, R. Gorlick (eds.), Current Advances in Osteosarcoma, Advances in Experimental Medicine and Biology ...

Author: Eugenie S. Kleinerman

Publisher: Springer Nature

ISBN: 9783030430320

Category: Medical

Page: 212

View: 150

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This thoroughly revised second edition complied in 2 books is an up-to-date overview of the current clinical advances in sarcoma and osteosarcoma. The new edition features detailed, in-depth discussions of microRNAs in osteosarcoma, historical perspectives of chemotherapy in the treatment of the disease, tumor targeted IL12 therapy and HER2 targeted therapy, the role of enhancer elements in regulating the prometastatic transcriptional program and more. Further, these essential volumes also includes new insights on Wnt signaling in osteosarcoma, the role of genomics, genetically modified T-cell therapy, liquid biopsy, oncolytic viruses, immunophenotyping, receptor tyrosine kinases and epigenetic-focused approaches for treatment of osteosarcoma metastases, as well as thoughts on the current standard of treatment for patients suffering from these cancers. In the years since the previous edition, there have been numerous new developments in this rapidly changing field; this new edition is both timely and urgently needed. When taken together these companion volumes, Current Clinical (Book 1) and Scientific (Book 2) Advances in Osteosarcoma, are a timely and urgently needed guide for laboratory investigators and clinical oncologists focused in sarcoma.
2020-06-01 By Eugenie S. Kleinerman

Research Perspectives: Tumor Biology, Organ Microenvironment, Potential New Therapeutic Targets, ... In a more recent study, Smida et al. evaluated a larger cohort of 160 pretreatment osteosarcoma samples using high-density arrays.

Author: Eugenie S. Kleinerman

Publisher: Springer Nature

ISBN: 9783030430856

Category: Medical

Page: 233

View: 447

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This thoroughly revised second edition is an up-to-date overview of the new advances in the knowledge of the basic science in sarcoma and osteosarcoma. It features detailed, in-depth discussions of microRNAs in osteosarcoma, historical perspectives of chemotherapy in the treatment of the disease, tumor targeted IL12 therapy and HER2 targeted therapy, the role of enhancer elements in regulating the prometastatic transcriptional program and more. Further, this essential volume also includes new insights on Wnt signaling in osteosarcoma, the role of genomics, genetically modified T-cell therapy, liquid biopsy, oncolytic viruses, immunophenotyping, receptor tyrosine kinases and epigenetic-focused approaches for treatment of osteosarcoma metastases, as well as thoughts on the current standard of treatment for patients suffering from these cancers. In the years since the previous edition, there have been numerous new developments in this rapidly changing field; this new edition is both timely and urgently needed. When taken together these companion volumes, Current Clinical (Book 1) and Scientific (Book 2) Advances in Osteosarcoma, are a timely and urgently needed guide for laboratory investigators and clinical oncologists.
2020-08-07 By Eugenie S. Kleinerman

When taken together these companion volumes, Current Clinical (Book 1) and Scientific (Book 2) Advances in Osteosarcoma, are a timely and urgently needed guide for laboratory investigators and clinical oncologists.

Author:

Publisher:

ISBN: 3030430863

Category: Osteosarcoma

Page:

View: 108

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This thoroughly revised second edition is an up-to-date overview of the new advances in the knowledge of the basic science in sarcoma and osteosarcoma. It features detailed, in-depth discussions of microRNAs in osteosarcoma, historical perspectives of chemotherapy in the treatment of the disease, tumor targeted IL12 therapy and HER2 targeted therapy, the role of enhancer elements in regulating the prometastatic transcriptional program and more. Further, this essential volume also includes new insights on Wnt signaling in osteosarcoma, the role of genomics, genetically modified T-cell therapy, liquid biopsy, oncolytic viruses, immunophenotyping, receptor tyrosine kinases and epigenetic-focused approaches for treatment of osteosarcoma metastases, as well as thoughts on the current standard of treatment for patients suffering from these cancers. In the years since the previous edition, there have been numerous new developments in this rapidly changing field; this new edition is both timely and urgently needed. When taken together these companion volumes, Current Clinical (Book 1) and Scientific (Book 2) Advances in Osteosarcoma, are a timely and urgently needed guide for laboratory investigators and clinical oncologists.
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This book is a combination of recent advances in two major areas of orthopaedics: Bone tumours and Osteoarthritis. All chapters are contributed by well-known researchers and surgeons in Orthopaedics working across the globe.

Author: Hiran Amarasekera

Publisher: BoD – Books on Demand

ISBN: 9781839689239

Category: Medical

Page: 152

View: 906

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This book is a combination of recent advances in two major areas of orthopaedics: Bone tumours and Osteoarthritis. All chapters are contributed by well-known researchers and surgeons in Orthopaedics working across the globe. The book is divided into two major parts for clarity. All authors have contributed their original research, their experience in the field, and the recent advances that will keep the reader well informed and up to date in our understanding of bone tumours and osteoarthritis. This is a “must have” reference book for any medical library or an individual who is keen to update and have CME (continuous medical education) points added to their learning.
2021-09-01 By Hiran Amarasekera

It was also recommended that when the patients suffering from osteosarcoma are referred for radiation therapy, the type of treatment, such as combined chemotherapy, must be considered in light of recent developments in chemotherapy for ...

Author: Atsumasa Uchida

Publisher: Springer Science & Business Media

ISBN: 9784431683643

Category: Medical

Page: 289

View: 411

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Recent advances in diagnostic technology, including imaging, gene analysis and histopathology, form one cornerstone of this update for health care specialists treating patients with musculoskeletal cancer. The other cornerstone consists of chemotherapy and radiotherapy, as well as highlights in surgical treatment and rehabilitation. The complete structure conveys a systematic understanding of musculoskeletal oncology, with sections on limb saving procedures, reconstruction methods of bone and soft tissues, tumor prosthesis and spinal reconstruction in metastatic bone tumors. All the information is placed under the encompassing goal of total care for the patient.
2013-11-09 By Atsumasa Uchida

As a glycosaminoglycan mimetic, its properties in bone and cartilage regeneration, angiogenesis, and osteosarcoma treatment are currently under study as promising applications. The use of polysaccharides for human health requires the ...

Author: A Mendez-Vilas

Publisher: World Scientific

ISBN: 9789814405058

Category: Medical

Page: 696

View: 544

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This book offers the latest scientific research on applied microbiology presented at the IV International Conference on Environmental, Industrial and Applied Microbiology (BioMicroWorld2011) held in Spain in 2011. A wide-ranging set of topics including agriculture, environmental, food, industrial and medical microbiology makes this book interesting not only for microbiologists, but also for anyone who likes to keep up with cutting-edge research in microbiology and microbial biotechnology. Readers will find a major collection of knowledge, approaches, methods and discussions on the latest advances and challenges in applied microbiology in a compilation of 136 chapters written by active researchers in the field from around the world. The topics covered in this single volume include biodegradation of pollutants, water, soil and plant microorganisms, biosurfactants, antimicrobial natural products, antimicrobial susceptibility, antimicrobial resistance, human pathogens, food microorganisms, fermentation, biotechnologically relevant enzymes and proteins, microbial physiology, metabolism and gene expression mainly, although many other subjects are also discussed. Sample Chapter(s) A microcosm study on the die-off response of the indicator bacteria, Enterococcus faecium and Enterococcus faecalis (267 KB) Contents:Agriculture, Soil, Environmental and Marine–Aquatic MicrobiologyFood MicrobiologyIndustrial Microbiology. Methods. Quantitative Models and BioinformaticsMedical and Pharmaceutical Microbiology. Antimicrobial Agents and ChemotherapyMicrobial Physiology, Metabolism and Gene ExpressionBiotechnologically Relevant Enzymes and Proteins Readership: Professionals, microbiologists, clinicians, (bio)chemists, physicists, and engineers. Keywords:Microorganisms;Applied Microbiology;Environmental Microbiology;Industrial Microbiology;Microbial Biotechnology;BioMicroWorld2011 Conference Proceedings Book;Mendez-VilasKey Features:The topics covered in this single volume include biodegradation of pollutants, water, soil and plant microorganisms, biosurfactants, antimicrobial natural products, antimicrobial susceptibility, antimicrobial resistance, human pathogens, food microorganisms, fermentation, biotechnologically relevant enzymes and proteins, microbial physiology, metabolism and gene expression mainly, although many other subjects are also discussed
2012-06-21 By A Mendez-Vilas

This book is titled Osteosarcoma - Diagnosis, Mechanisms, and Translational Developments, and focuses on recent advancements and novel ideas in osteosarcoma research.

Author: Matthew Gregory Cable

Publisher: BoD – Books on Demand

ISBN: 9781839680144

Category: Medical

Page: 130

View: 955

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This book is titled Osteosarcoma - Diagnosis, Mechanisms, and Translational Developments, and focuses on recent advancements and novel ideas in osteosarcoma research. In a manner of speaking, we have taken the multidisciplinary mindset essential for treating osteosarcoma and broadened it to include other areas of cancer research. By learning from gains in other areas of oncology, such as new lncRNAs, the understanding of cancer metabolism and oxidative phosphorylation, and new chemotherapy agents, we can apply them to the niche of osteosarcoma for treatment development. By drawing more attention to these novel and clever discoveries, we hope to continue this enthusiasm for advancements in basic and translational research in the field of osteosarcoma.
2019-12-04 By Matthew Gregory Cable

The knowledge presented here will lead to further inspiration, ideas, and novel insights into the field of osteosarcoma research. Hopefully, this work will foster improvement of the prognosis for patients suffering from the disease.

Author: Kanya Honoki

Publisher: BoD – Books on Demand

ISBN: 9789535130956

Category: Medical

Page: 254

View: 282

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Osteosarcoma is the most common malignant bone tumor and mainly affects children, adolescents, and young adults. Osteosarcoma shows significant genetic instability, resulting in very complex biology with multifaceted cellular and molecular mechanisms and behavior. Although clinical outcomes, both prognostic and functional, of osteosarcoma dramatically improved in the 1980s, the prognoses of the patients with relapsed and/or metastatic disease remained very poor in spite of our continuous efforts to overcome this difficulty. This book aims to delve into the current advances of basic and clinical sciences in osteosarcoma that are guiding the future directions of its research and clinical practice. The knowledge presented here will lead to further inspiration, ideas, and novel insights into the field of osteosarcoma research. Hopefully, this work will foster improvement of the prognosis for patients suffering from the disease.
2017-04-26 By Kanya Honoki

For example, the 5-year survival rate for localized osteosarcoma is about 70.1%, whereas the 5year survival in metastatic osteosarcoma is 31.6%.49–55 of the bone before treatment.46 Calculation of fluoride bone plasma clearance (kinetic ...

Author: Habib Zaidi

Publisher: Elsevier Health Sciences

ISBN: 9780323757881

Category: Medical

Page: 240

View: 563

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This issue of PET Clinics focuses on Recent Advances in Imaging with PET, CT, and MR Techniques and is edited by Drs. Habib Zaidi, Abass Alavi and Drew A. Torigian. Articles will include: Total-body PET imaging: Developments in instrumentation; Prospects for total-body PET imaging using plastic scintillators; Total-body imaging: Potential clinical applications; New challenges for PET image reconstruction for total-body imaging; Advances in preclinical PET instrumentation; Applications of hybrid PET/MRI in CNS disorders; Applications of hybrid PET-MRI in MSK disorders; Assessment of total body atherosclerosis burden by PET-CT; Recent advances on CT and MR imaging in radiology; Potential impact of Total Body PET imaging in measuring global disease burden in systemic inflammatory disorders; Applications of PET-MRI in CV disorders; and more!
2020-10-08 By Habib Zaidi